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However, current evidence suggests that the development of such antibodies does not significantly reduce the drugs effectiveness or cause any distinct adverse reaction profile

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Isocratic enantiomer separation was at a flow rate of 1 mL min 1 at 27C using a mobile phase consisting of 85% (v/v) 100 mM ammonium acetate, 1 mM Cu(II)-acetate (pH 4.5, with acetic acid) and 15% (v/v) 2-propanol