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Access this article Similar content being viewed by others Abbreviations Acyl-CoA: Acyl-coenzyme A AES: Androgen Excess Society ASRM: American Society for Reproductive Medicine BMI: Body mass index CVD: Cardiovascular disease DHEA: Dehydroepiandrosterone ESHRE: European Society of Human Reproduction and Embryology FAI: Free androgen index FPG: Fasting plasma glucose HC: Hip circumference HDL-c: High density lipoprotein-cholesterol HOMA-IR: Homeostatic model assessment for insulin resistance IPAQ: International physical activity questionnaire LDL-c: Low-density lipoprotein-cholesterol LH: Luteinizing hormone MET-h: Metabolic equivalent task hours NAFLD: Nonalcoholic fatty liver disease NIH: National Institutes of Health PCOS: Polycystic ovary syndrome QUICKI: Quantitative insulin sensitivity check index SHBG: Sex hormone-binding globulin T2DM: Type 2 diabetes mellitus TC: Total cholesterol TG: Triglyceride VLDL: Very low-density lipoprotein WC: Waist circumference References Condorelli RA, Calogero AE, Di Mauro M, Mongioi LM, Cannarella R, Rosta G et al (2018) Androgen excess and metabolic disorders in women with PCOS: beyond the body mass index

Potential clinical implications and challenges with the new obesity pharmacotherapies A new era in obesity management Tirzepatide has received FDA and EMA approval for chronic weight management and results in 20% mean WL in people without T2D

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Theories include alteration of bile acid metabolism, small intestinal bacterial overgrowth, effects on intestinal motility and interference by metformin on vitamin B12-intrinsic factor absorption in the terminal ileum