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33, 34 While covalent modification of C75 by electrophilic small molecules has been reported to allosterically inhibit the enzymatic activity of ADA and lead to antiproliferation of lymphocytic cells, 35 there was no covalent modifier identified to target C153 or C154 that is located close to the active site of ADA (Figure 4F)
Lancet Diabetes Endocrinol (2021) 9:22534
For example, expired antibiotics may fail to treat bacterial infections, leading to serious illness and antibiotic resistance
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