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Although streaks that develop in childhood are usually benign, 26 single bands that are dark in color or wide ( 6 mm), become darker or wider with time, are associated with nail dystrophy, or have extension of pigmentation beyond the nail fold warrant consideration of biopsy of the nail matrix to exclude melanoma

Roughly 1015% of patients are clinically considered non-responders to semaglutide meaning they lose less than 5% of body weight even at the maximum dose with good adherence

Healthcare providers closely monitor for side effects, particularly gastrointestinal issues and dehydration

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