In contrast, high glucose-induced GLP-1 release was unaffected by PPAR/ inhibition, suggesting that C3G-induced PG gene transcription to increase GLP-1 levels in STC-1 cells was specifically mediated through the PPAR/--catenin-TCF signaling pathway
The secondary endpoint was hospitalization for heart failure
While GLP-1 and GIP primarily suppress appetite and regulate blood sugar, glucagon increases energy expenditure through thermogenesis
JWU-A021 stimulates GLP-1 release from primary intestinal cell cultures The GLP-1 secretagogue action of JWU-A021 was also tested using mouse intestine primary cell cultures enriched in L-cells
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