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Activation of endosomal TLR7/8 during SARS-CoV-2 may increase the inflammatory response resulting in severe and potentially lethal immunopathological effects in COVID-19 patients as consequence of the simultaneous release of pro-inflammatory cytokines and chemokines

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Risk Factors and Frequency for Rotor Syndrome (Rotor type hyperbilirubinemia) Rotor syndrome was initially identified in 1948 by Rotor and his team in the Philippines, and since that time, cases have cropped up all over the world, including the US, Japan, France, Mexico, Papua New Guinea, and Italy

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