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The working mechanism of affinity chromatography is often associated with the lock-and-key mechanism of enzyme-substrate interaction

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PMID 34832885

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For the principal component analysis (PCA) the variance was filtered by default optimisation settings and a predefined standard deviation of p = 0.005 comparing untreated HepG2 and HepG2 ATP7B-KO cells resulted in a false discovery rate (FDR) of q = 0.01788