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Br J Biomed Sci 2013;70(2):7579

AD is the most common form of dementia, with an estimated prevalence of 416 million persons worldwide from 2010 to 2020 and growing incidence rates (increasing by 147.95% from 1990 to 2019) (Gustavsson et al ., Reference Gustavsson, Norton, Fast, Frlich, Georges, Holzapfel, Kirabali, Krolak-Salmon, Rossini, Ferretti, Lanman, Chadha and van der Flier2023

Meanwhile, Mn 2+ catalyzed H 2 O 2 to produce toxic OH through Fenton-like reactions under the assistance of HCO 3 2- and high temperatures, which was engineered by an MS-BSA-triggered photothermal effect, potentiating a GSH depletion-prompted robust anticancer effect

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