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[cite_start]Intranasal administration specifically bypasses first-pass hepatic metabolism and the blood-brain barrier (BBB) via olfactory and trigeminal nerve pathways[cite: 396]

To this point, we recognized that peptidyl GHRPs are composed in large part of D-amino acid isomers which, unlike the l-isomers, are resistant to endopeptidase attack in the gut (28)

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