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If cramps are severe, nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce prostaglandin production and alleviate both cramps and diarrhea

IL-1 regulates the Cyp7a1 gene and serum total cholesterol level at steady state in mice

This does two things: Keeps NAD+ precursors available for actual NAD+ synthesis Depletes the methyl groups that fat cells use to maintain their metabolic "off" state The second effect is the more interesting one

IL-6 receptor antagonists like tocilizumab block IL-6 signaling

Perhaps this explains why people have difficulty losing weight, maintaining bone health, and achieving sexual satisfaction