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Interestingly, nonfatal heart attack showed the largest risk reduction among the three primary outcome components, contrasting with the earlier PIONEER 6 trial where cardiovascular death was the dominant benefitlikely because SOUL's longer follow-up and larger sample size (approximately three times that of PIONEER 6) allowed more comprehensive assessment of cardiovascular outcomes

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13 There was a 12% reduction in 3-point Major Adverse Cardiovascular Events (MACE: cardiovascular death, non-fatal myocardial infarction and non-fatal stroke) (HR=0.88, 95% CI 0.79 to 0.99)

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