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PD-1/PD-L1 checkpoint-blocking antibodies are thought to act primarily in the tumor microenvironment, where PD-L1 is expressed by tumor cells (174), myeloid cells (168, 203, 204), LECs (94, 95, 98), blood endothelial cells (95), B cells (205, 206), T cells (207), dendritic cells (30, 203) and NK cells (208, 209)

Since FBF interacts with GLD-3 via its conserved RNA-binding domain (Wu et al., 2013), it is possible that PUF-8 RNA-binding domain might interact with GLD-3 as well

The brain atrophy of GCLC-KO mice was also evidenced by MRI analyses (Fig

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