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Nevertheless, our findings in erythrocytes and previously published in SCD cardiac tissues 46 support that, in addition to inflammation suppression 23 and fetal globin induction 31,63,64 , DMF displays anti-oxidative and ferroptosis stress effects to alleviate SCD clinical severity, and therefore, might be pursued as a new treatment option

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106,107 Unlike siRNA-mediated gene silencing, miRNAs can simultaneously recognize and regulate the expression of multiple target mRNAs due to their low complementarity

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