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Lind M, Imberg H, Coleman RL, Nerman O, Holman RR (2021) Historical HbA 1c values may explain the type 2 diabetes legacy effect: UKPDS 88

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Evidence indicates that ER stress was increased, thereby resulting in impaired insulin receptor signaling in the hippocampus and frontal cortex of obese rats, which is also caused by the activation of JNK.67 Therefore, diabetes and ER stress are vicious cycles in the brain, and IR is the key link

However, alterations of the redox balance of GSH can impair normal cellular metabolism, making cells vulnerable