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FDA adverse event data (as of early 2025) 455+ adverse event reports linked to compounded semaglutide 320+ adverse event reports linked to compounded tirzepatide Many involved dosing errors from multidose vials, some requiring hospitalization Reports include severe nausea, vomiting, dehydration, and overdose symptoms Documented contamination, mislabeling, and counterfeit product cases 1

e-Pub 2022

Vojdani A, Mumper E, Granpeesheh D, Mielke L, Traver D, Bock K et al

Because of this mechanism, some patients experience drowsiness when injecting in the evening, which is actually aligned with the intended timing of the protocol

J., Schembri-Wismayer, D