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Community sources and trial data describe these effects at 0.5 mg: Dry mouth (most common), insomnia (more common with afternoon or evening dosing, per community sources), elevated heart rate (5-10 bpm), constipation, mild mood elevation

The once weekly subcutaneous formulation underwent evaluation in the SUSTAIN program (Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes), which comprised 13 distinct randomized clinical phase 3a and 3b trials [7]