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This hypothesis is a result of the discovery that GPX4 inactivation-induced ferroptosis is caused mostly by nonmitochondrial lipid peroxidation [66]

Notably, lactylation also acts as a key mediator for some drugs in cerebral IRI protection, such as Buyang Huanwu Decoction, which effectively inhibits cerebral IRI deterioration by suppressing extensive lysine lactylation and specific H3K18 lactylation [117]

February 17, 2024

Biomedicines 8 , 277 (2020)

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