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Restoration of mtGSH by GSH ethyl ester limits oxidative stress and suppresses NLRP3 activation in neuronal models of amyloid toxicity 64

doi: 10.3390/molecules24183251

Its high selectivity for MC1R compared to the broader receptor profile of Melanotan-II makes it particularly valuable for studies examining receptor subtype selectivity, structure-activity relationships, and the mechanistic role of -MSH analogues under controlled experimental conditions

TIRF movies were obtained using a Nikon Eclipse TE2000-S microscope (Nikon) and TIRF assembly (Cairn), employing a 100/1.49 NA oil-immersion objective, QuantEM 512SC EMCCD camera (Photometrics), 491 nm laser excitation, 535/25 nm emission filter and environmental stage-top chamber (Okolab) with base and lid heated to 37 C