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Olpasiran (AMG890) has shown a dose-dependent significant reduction in Lp(a) concentrations [235], OCEAN(a)-Outcome (NCT05581303) is an ongoing phase III clinical trial designed to study its long-term effects on MACE

Dizziness was reported in the 2023 Phase 2 trial but was less frequent than gastrointestinal adverse effects

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Glycaemic control typically improves within the first few weeks, whilst significant weight loss and associated energy improvements may take 3-6 months to become apparent