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When this barrier is disrupted, RPE cell activation occurs, leading to the proliferation, epithelial-mesenchymal transition (EMT), and secretion of extracellular matrix molecules, thus promoting vitreoretinal disorders, including proliferative vitreoretinopathy (PVR), age-related macular degeneration (AMD), and proliferative diabetic retinopathy (PDR) [1,2,3]

(2) Evidence on B12 and cancer is mixed overall, with some studies showing higher risk, some lower, and some none

Shen, None

This is the optimal configuration for high-dose maintenance

1f), supporting changes in mitochondrial morphology and network formation