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Stimulation of calcium/NOS/CK1 signaling by cedrol triggers eryptosis and hemolysis in red blood cells
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Minimizing exposure to food toxins and adopting a healthy diet can be particularly game changing for individuals with MTHFR mutations
Common causes / risk factors * Repetitive hand use (typing, manual work) * Pregnancy * Diabetes * Hypothyroidism * Rheumatoid arthritis * Obesity Symptoms (classic pattern) * Numbness & tingling in: * Thumb, index, middle, and half of ring finger * Pain (may radiate to forearm) * Weak grip * Thenar muscle wasting (late sign) * Symptoms worse at night Clinical tests * Phalens test wrist flexion reproduces symptoms * Tinels sign tapping over wrist causes tingling Diagnosis * Mostly clinical * Nerve conduction studies confirm severity Management Conservative (mildmoderate) * Wrist splint (especially at night) * Activity modification * NSAIDs * Steroid injections Definitive * Surgical decompression (release of flexor retinaculum) * Permanent nerve damage if untreated LOAF muscles affected by median nerve * Lumbricals (1st & 2nd) * Opponens pollicis * Abductor pollicis brevis * Flexor pollicis brevis
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