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Discussion Cellular senescence, triggered by diverse external and internal stressors, serves as a protective response that prevents the proliferation of impaired cells, thereby conferring resistance to cancer 45,468

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A typical schedule: Weeks 1, 4 : 0.25 mg/kg/day (e.g., 20 mg for a 75 kg patient) Week 4 labs : if triglycerides remain below 300 mg/dL and ALT/AST are within 1.5x upper limits of normal, increase to 0.5 mg/kg/day Week 8 labs : if stable, consider escalation to 0.75 mg/kg/day Week 12+ : hold at the maximum tolerated dose until cumulative target is reached The initial flare (worsening of acne in weeks 2, 4) occurs in older adults just as it does in younger patients