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Ipamorelin is a growth hormone (GH) secretagogue that mimics ghrelin and selectively binds the same GHSR-1a receptor as endogenous ghrelin [10]

Paradoxically, several pathways implicated in PD pathogenesisincluding glycogen synthase kinase-3 (GSK-3), p38 MAPK, and nuclear factor-B (NF-B)are upregulated and inhibit Nrf2 activity (Mogi et al., 2007

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In addition, it is also hypothesized that altered gastric physiology may indirectly reduce intrinsic factor levels