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Consistent with this, AMPK deletion decreases the activation of AKT and promotes M1 macrophage polarization [89]

Expression profiling and genetic alterations of the selenoproteins GI-GPx and SePP in colorectal carcinogenesis

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Nunn A, Guy G, Bell JD

It should also be noted that ROS generates a metabolic syndrome due to changes in energy metabolism, activation of RNS, xanthine oxidase, increased expression of inflammatory mediators, and low levels of GPx and other antioxidant enzymes