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Mechanistic pathway is well-characterized in cell and animal models

However, although we think deeply towards the refinement of current approaches and techniques, as well as towards the potential for discovering future applications, we draw heavily upon the pioneering discoveries of functional neurosurgery and the initial findings of deep brain stimulation (DBS)

Therapy with a GLP-1 RA or sodium-glucose cotransporter 2 inhibitor (SGLT2 inhibitor) that has proven CV benefit is recommended for initial therapy, with or without metformin based on glycemic needs, in patients with indicators of high-risk or established CV disease

Most patients start to experience these treatment benefits during the initial weeks of their therapy

Each compound targets a distinct biological pathway with minimal overlap, allowing researchers to examine four separate mechanisms simultaneously