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When FOXO4-DRI was applied to senescent Leydig cells, it caused p53 to be excluded from the cell nucleus and induced apoptosis in these cells

To confirm this hypothesis, we conducted cytotoxicity assays, and half-maximal inhibitory concentration (IC 50 ) values of the agents against ATC cells and normal thyroid cells were determined using the standard MTT assay (Fig

Peptide-containing supernatant was collected by centrifugation (12,500 g for 5 minutes) and desalted on a C18 column

About 98% of your L-carnitine stores are contained in your muscles, along with trace amounts in your liver and blood

However, this reconstitution advantage was lost in competitive transplantations, where the volume of whole bone marrow containing 300 HSCs of either aged WT or Mda5 -/- animals (CD45.2) was transplanted with 0.5 million bone marrow cells from a young donor (CD45.1) into lethally irradiated recipients (CD45.1/.2) (Supplementary Fig