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MHM, the process responsible for supplying COMT with the methyl group necessary for 2-ME synthesis, could be compensatorily activated in preeclampsia to supply methyl groups enough to sustain adequate concentration of 2-ME (83)

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Our findings suggest that P-SF3B1 engages with the upper loop of the U6-ISL element, likely contributing to the stabilization of the RNA structures required for splicing catalysis