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In order to decrease the amount of tau phosphorylation and the formation of neurofibrillary tangles, siRNA against microtubule-associated protein tau (MAPT) has been shown to have a protective effect on synapse function and neuronal survival (101)

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Of note, the results of these additional five groups in all the measured parameters and the histopathological findings were non-significant, compared to those of the normal control group

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