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However, the current evidence base is largely preclinical, and no large-scale human clinical trials have confirmed its efficacy

In spontaneously hypertensive rats, the well-studied HDAC inhibitor valproic acid has been shown to lower blood pressure, inflammatory cytokines, hypertrophy markers, and ROS levels [78]

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However, when combined with sulfonylureas or insulin, dose adjustments of these concomitant medications may be necessary to prevent hypoglycaemic episodes

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