This therapeutic effect was mechanistically linked to reductions in pro-inflammatory cytokines (TNF-, IL-1), enhancement of antioxidant defenses (e.g., increased superoxide dismutase activity), suppression of apoptosis via caspase-3 inhibition, and modulation of NF-B pathwayscollectively yielding neuroprotection and symptomatic relief ( Curcumin shows therapeutic potential for managing peripheral neuropathic pain through multiple mechanisms (Zhang et al., 2020b)
Immune Dysregulation and Frequent Infections: By optimizing the cellular redox environment, glutathione supports the proliferation and activity of Natural Killer (NK) cells and other vital immune components, enhancing the bodys ability to fight off latent viral reactivations
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In pulmonary fibroblasts, glutamine-derived glutamate contributes to the synthesis of alanine and proline, key substrates for collagen production