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As the biosynthesis process depends on the addition of nitrogen sources, such as glycine and hypoxanthine, selection for strains resistant to the adenine antimetabolite, 4-aminopyrazolo (3, 4-d) pyrimidine, improved production (Park et al., 2007, Sugimoto et al., 2010
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In turn, this can lead to a state of chronic tendinosis rather than repair
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