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"Two concentrations of topical tretinoin (retinoic acid) cause similar improvement of photoaging but different degrees of irritation: a double-blind, vehicle-controlled comparison of 0.1% and 0.025% tretinoin creams." Archives of dermatology 131.9 (1995): 1037-1044

Peak levels of aspirin appear in the systemic circulation 30-60 mins following ingestion of an immediate release aspirin tablet, with the rate of absorption being dependent on the rate of tablet disintegration & dissolution, the pH at the mucosal surface, and gastric emptying time (Grosser et al, 2023)

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PubMed Fatemeh G, Sajjad M, Niloufar R, et al

Feng, X., Sureda, A., Jafari, S., Memariani, Z., Tewari, D., Annunziata, G., Barrea, L., Hassan, T