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Glutathione naturally inhibits tyrosinase activity, slowing down the overproduction of melanin that leads to dark spots, hyperpigmentation, and uneven tone

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The 6-pyruvoyltetrahydropterin synthase enzyme is encoded by the PTS gene which is located on chromosome 11q23.1 and is composed of 6 exons that encode a 145 amino acid protein

This weight gain results from decreased metabolic rate and may be challenging to address with lifestyle interventions alone, even with thyroid hormone replacement therapy

Barrett AW, Morgan M, Ramsay AD, Farthing PM, Newman L, Speight PM (2002) A clinicopathologic and immunohistochemical analysis of melanotic neuroectodermal tumor of infancy