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Methods After systematic literature search, screening and full-text evaluation, a total of 34 articles, including 9 bacterial/biofilm, 13 soft-tissue (1 overlapping between bacterial and soft-tissue), and 13 clinical studies were selected

They advocate for a treatment approach that is: Symptom-led : Recognising that many patients become symptomatic well before their next scheduled dose, meaning they are being under-treated

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A clearer understanding of ivermectin resistance mechanisms and the research gaps in this topic will help us prepare for both the monitoring of resistance in Anopheles mosquitoes, and the potential use of synergists in combination with ivermectin