how is semaglutide different than tirzepatide vs Semaglutide: Weight Loss, Side Effects, Uses Semaglutide vs Tirzepatide: Key Differences

Tirzepatide is a dual-receptor GLP-1/GIP

Following withdrawal of treatment, muscle size returned to baseline by week 28, showing the reversibility of the effect

J Gastrointest Surg 26(3):671683 Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D et al (2018) The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD

For context on how these agents fit into the broader landscape, see our overview of what peptides are and how they are studied

it requires ongoing injections, and discontinuation can lead to rapid weight regain, undermining long-term weight management efforts