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Clinical studies have shown that GLP-1R reduces ROS levels, the mitochondrial membrane potential and mitochondrial apoptosis in patients with diabetes (Wang et al., 2021), as well as alleviating levels of OS and attenuating low-grade inflammation (Zhang et al., 2018)

By understanding the roles of receptor dimers, one would hope that designed drugs that target a specific dimer would be beneficial in pharmacological treatment

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After screening the abstracts of the articles retrieved, 2 of the authors (DMC and JPC) performed a full-text review to select relevant articles