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For diabetic retinopathy, GLP-1RAs are associated with the early worsening phenomenon linked to rapid glycemic control, a signal not typically observed with SGLT2 inhibitors, which generally show a neutral or modestly protective effect

Not only were depression and anxiety improved with some of these medications, they actually seem to help suicidality, he says

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5 Future directions The potential of GLP-1RAs as dual-action therapies, targeting both metabolic dysfunction and immune dysregulation, makes them particularly compelling candidates for early PsA, where intervention may alter disease trajectory

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