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Funding This study was supported by grant from National Natural Science Foundation of (82100806, 82270802, 82170775, 82370765), The Open Project of Hubei Key Laboratory 2023KFZZ009 and The Fundamental Research Funds for the Central Universities 2042023kf0022

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Proteins in total homogenates (2040 g) or nuclear extracts (40 g) were resolved by 10% SDS-PAGE and immunoblotted using following primary antibodies: chicken polyclonal antibodies against mouse GCLM 7 and mouse ALDH1A1 60

At indicated time points buffer or Glr1 (1.25 U/ml final concentration

7 For Heartburn/Reflux: Avoiding personal trigger foods (often spicy, fatty, acidic, caffeine, chocolate, peppermint) is important