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Some people also report a lower appetite, which may be part of how the medication supports weight loss

The maintenance phase requires as much intentional engagement with nutrition, activity, sleep, and medication adherence as the weight loss phase did. Part of the reason is biological

Timeline and Severity of Semaglutide-Related Headaches Most patients report headache onset within the first 35 days after their initial semaglutide injection, with peak intensity typically occurring during days 714

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This may make it easier to regain weight if treatment is stopped, especially since many people discontinue GLP-1 medications within the first year