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It has been observed that glutamate production through the appropriate function of GDH pathway has a role in the mitochondrial retrograde signaling that affects changes in nuclear gene expression related to nutrient sensing and TOR signaling [26, 98], aging [99, 100] metabolism [20] and as recently shown, in different types of cancer [101,102,103,104,105,106,107,108]

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Falutz J, Allas S, Blot K, Potvin D, Kotler D, Somero M, et al

All immunofluorescence images were obtained using an LMS700 laser scanning confocal microscope (Zeiss, Oberkochen, Germany), and the images were analyzed using Image-Pro plus 6.0 software (Media Cybernetics, Silver Spring, MD, USA)