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consider calcifediol when faster repletion or persistent SHPT is relevant), avoid mega-bolus dosing, and reserve active VDRAs for clear SHPT indications with careful calciumphosphateparathyroid hormone (PTH) monitoringrather than positioning vitamin D as disease-modifying therapy for unselected CKD

Mitochondrial integrity regulated by lipid metabolism is a cell-intrinsic checkpoint for Treg suppressive function

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The absence of one B vitamin can affect the activity of others, highlighting their interdependence

However, Jones and colleagues demonstrated a direct relationship between levels of IL-1 and TNF- in healthy human subjects and the plasma cysteine redox potential, as determined by the concentration of reduced cysteine to cystine, its oxidized disulfide form [144]