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The topic is complex, and the leaching of excessive metal ions into water causes serious gastrointestinal, renal, hepatic, and central nervous system problems

Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death

Their system protected siRNA from degradation under normal conditions but enabled rapid release in GSH-rich cancer environments, achieving widespread brain distribution within 2 h and persistence up to 24 h

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These findings underscore that GSH regulates ferroptosis not only through peroxide detoxification but also by coordinating iron trafficking and Fe-S cluster integrity, thereby coupling redox defense to core metabolic fitness