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By assisting the liver in removing these toxins, coffee enemas can help to alleviate these symptoms and promote a sense of well-being

doi: 10.1093/cid/cis1011 [DOI] [PMC free article] [PubMed] [Google Scholar] 263

A small amount of the drug is metabolized via the cytochrome P-450 pathway (to be specific, CYP3A4 and CYP2E1) into NAPQI, which is extremely toxic to liver tissue, as well as being a strong biochemical oxidizer

Antioxidants 11 (9): 1728

J Exp Bot 66:17692185 Arnaud D, Deeks MJ, Smirnoff N (2023) RBOHF activates stomatal immunity by modulating both reactive oxygen species and apoplastic pH dynamics in Arabidopsis