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Simultaneously, its GLP-1 receptor agonist activity promotes insulin release, suppresses glucagon secretion, slows gastric emptying, and reduces appetite through central nervous system pathways

Here we report the design and preclinical evaluation of a molecule that covalently links the PPAR/ dual-agonist tesaglitazar to a GLP-1 receptor agonist (GLP-1RA) to allow for GLP-1R-dependent cellular delivery of tesaglitazar

M.DanielM.GunnJ

The binding of BECN1 to SLC7A11, a core component of xCT, inhibits the xCT function and promotes ferroptosis [62] , indicating that BECN1 is a key ferroptosis inducer [63]