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One class of drugs that are commonly debated about for their interactions with semaglutide are antidepressants, specifically selective serotonin reuptake inhibitors (SSRIs) like Lexapro or Zoloft

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Mechanism 2: Prevention of Thyroid Protein Oxidation & Autoantigen Formation Oxidative stress in the thyroid doesn't just damage cells - it chemically modifies thyroid proteins, particularly thyroglobulin (Tg) and thyroid peroxidase (TPO)

This can damage the blood vessels that press on the trigeminal nerve and cause irritation or compression

The article shifts the real question to gastrointestinal tolerability rather than to absorption or potency