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Weight loss is dramatic but maintaining it requires continued medication

Duan J, Huang Y, Tan X, Chai T, Wu J, Zhang H, et al

The liver, in particular, is responsible for processing excess substances in the bloodstream

Curr Drug Metab 8(4):297306 Mishra SR, Mahapatra KK, Behera BP, Patra S, Bhol CS, Panigrahi DP et al (2021) Mitochondrial dysfunction as a driver of NLRP3 inflammasome activation and its modulation through mitophagy for potential therapeutics

The trial randomised adults with obesity who have achieved 5% WL by the end of the 12-week lead-in period (mean WL at the lead-in period was 6.9%) to placebo or tirzepatide