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Advantage: Potential for higher bioavailability than standard oral ingestion Challenge: Peptides are poorly absorbed through intact mucosal membranes without transport mechanisms Evidence: No studies confirm enhanced sublingual bioavailability for Dihexa Standard oral (swallowed): Tablets swallowed with water, absorbed through the gastrointestinal tract

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Collectively, these findings support the interactions of GHK and GHK-Cu complexes with mammalian models as research tools for studying redox regulation, peptide-mediated antioxidant signaling, and oxidative stress modulation

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