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Improvements in these markers suggest beneficial effects on glucose metabolism

An upregulation of KYAT1 and AADAT may reflect a compensatory astrocytic response to diminished KYNA availability, whereby upregulation of KAT enzymes and glutamate uptake mechanisms attempts to restore NMDAR inhibition and stabilize glutamatergic tone

The established ergogenic range for endurance is 3 to 6 mg per kg of body weight, taken 45 to 60 minutes before exercise, according to the International Society of Sports Nutrition position stand on caffeine

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