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Even more remarkable, a post-hoc analysis revealed that 14.1% of patients on the 9 mg dose and 12% on the 12 mg dose became completely free of knee pain at 68 weeks, compared to just 4.2% taking placebo

Subsequently, it declined steadily: 4.6 1.88 on day 2 ( P = 0.389), 3.57 2.43 on day 3 ( P = 0.036), 4.14 2.01 on day 4 ( P = 0.127), 4.07 2.21 on day 5 ( P = 0.127), 4.14 1.91 on day 6 ( P = 0.136) and 3.14 1.75 on day 7 ( P = 0.003)

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The treatment of type 2 diabetes requires positive modulation of GLP-1R to inhibit glucagon secretion and stimulate insulin secretion in a glucose-dependent manner 2

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