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25 In vitro studies showed that GLP-1 receptor binding did not directly stimulate amylase or lipase release

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A 2021 review published in Nutrients found that GLP-1 receptor agonist use was associated with reduced dietary intake of multiple micronutrients including B12, particularly in patients following calorie-restricted eating patterns, supporting the rationale for monitoring B12 status during treatment even in patients without pre-existing deficiency risk factors

Ecnoglutide vs Semaglutide: Biased GLP-1 Agonist vs Proven Standard of Care Evidence-based comparison of ecnoglutide (cAMP-biased GLP-1 agonist) and semaglutide (selective GLP-1 agonist), including SLIMMER Phase 3, STEP, and SELECT trial data